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Citations (partial list)

Brain malformations and seizures by impaired chaperonin function of TRiC. Kraft F, Rodriguez-Aliaga P et al. Science. 2024 Nov 1;386(6721):516-525.

Small molecule assembly agonist alters the dynamics of hepatitis B virus core protein dimer and capsid. Kant R, Lee LS et al. J Am Chem Soc. 2024 Oct 23;146(42):28856-28865.

Mechanism of bacterial predation via ixotrophy. Lien YW, Amendola D et al. Science. 2024 Oct 18;386(6719):eadp0614.

Catalytic asymmetric fragmentation of cyclopropanes. Raut RK, Matsutani S et al. Science. 2024 Oct 11;386(6718):225-230.

Ribosomes hibernate on mitochondria during cellular stress. Gemin O, Gluc M et al. Nat Commun. 2024 Oct 8;15(1):8666.

Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations. You Q, Feng X et al. Commun Biol. 2024 Sep 28;7(1):1202.

Fibrin drives thromboinflammation and neuropathology in COVID-19. Ryu JK, Yan Z et al. Nature. 2024 Sep 26;633(8031):905–913.

Germline mutations in a G protein identify signaling cross-talk in T cells. Ham H, Jing H et al. Science. 2024 Sep 20;385(6715):eadd8947.

The hepatitis C virus envelope protein complex is a dimer of heterodimers. Augestad EH, Holmboe Olesen C et al. Nature. 2024 Sep 19;633(8030):704–709.

Binding of steroid substrates reveals the key to the productive transition of the cytochrome P450 OleP. Costanzo A, Fata F et al. Structure. 2024 Sep 5;32(9):1465-1476.e3.

Molecular architecture of coronavirus double-membrane vesicle pore complex. Huang Y, Wang T et al. Nature. 2024 Sep 5;633(8028):224–231.

FANCD2-FANCI surveys DNA and recognizes double- to single-stranded junctions. Alcón P, Kaczmarczyk AP et al. Nature. 2024 Aug 29;632(8027):1165–1173.

Leptospira interrogans encodes a canonical BamA and three novel noNterm Omp85 outer membrane protein paralogs. Bettin EB, Grassmann AA et al. Sci Rep. 2024 Aug 28;14(1):19958.

Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor. Saha S, Khanppnavar B et al. Cell. 2024 Aug 22;187(17):4751-4769.e25.

Transport and inhibition mechanisms of the human noradrenaline transporter. Hu T, Yu Z et al. Nature. 2024 Aug 22;632(8026):930–937.

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Kefauver JM, Hakala M et al. Nature. 2024 Aug 15;632(8025):664-671.

An integrative structural study of the human full-length RAD52 at 2.2 Å resolution. Balboni B, Marotta R et al. Commun Biol. 2024 Aug 8;7(1):956.

Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages. Yang Y, Shao Q et al. Nat Commun. 2024 Aug 2;15(1):6551.

Mechanism of PCNA loading by Ctf18-RFC for leading-strand DNA synthesis. Yuan Z, Georgescu R et al. Science. 2024 Aug 2;385(6708):eadk5901.

Molecular mechanism of ligand gating and opening of NMDA receptor. Chou TH, Epstein M et al. Nature. 2024 Aug 1;632(8023):209–217.

Bis-sulfonamido-2-phenylbenzoxazoles validate the GroES/EL chaperone system as a viable antibiotic target. Godek J, Sivinski J et al. J Am Chem Soc. 2024 Jul 31;146(30):20845-20856.

Structure of the Hir histone chaperone complex. Kim HJ, Szurgot MR et al. Mol Cell. 2024 Jul 25;84(14):2601-2617.e12.

Tubulin code eraser CCP5 binds branch glutamates by substrate deformation. Chen J, Zehr EA et al. Nature. 2024 Jul 25;631(8022):905–912.

A μ-opioid receptor modulator that works cooperatively with naloxone. O'Brien ES, Rangari VA et al. Nature. 2024 Jul 18;631(8021):686–693.

Molecular mechanism of plasmid elimination by the DdmDE defense system. Loeff L, Adams DW et al. Science. 2024 Jul 12;385(6705):188-194.

Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Hu X, Ao W et al. Nature. 2024 Jul 11;631(8020):459–466.

Evolution and host-specific adaptation of Pseudomonas aeruginosa. Weimann A, Dinan AM et al. Science. 2024 Jul 5;385(6704):eadi0908.

Electric nuclear quadrupole coupling reveals dissociation of HCl with a few water molecules. Xie F, Tikhonov DS, Schnell M. Science. 2024 Jun 28;384(6703):1435-1440.

Structural insights into the cross-exon to cross-intron spliceosome switch. Zhang Z, Kumar V et al. Nature. 2024 Jun 27;630(8018):1012-1019.

Kainate receptor channel opening and gating mechanism. Gangwar SP, Yelshanskaya MV et al. Nature. 2024 Jun 20;630(8017):762–768.

Structural mechanism of angiogenin activation by the ribosome. Loveland AB, Koh CS et al. Nature. 2024 Jun 20;630(8017):769–776.

Structural pharmacology and therapeutic potential of 5-methoxytryptamines. Warren AL, Lankri D et al. Nature. 2024 Jun 6;629(8015):237–246.

Stepwise activation of a metabotropic glutamate receptor. Krishna Kumar K, Wang H et al. Nature. 2024 May 23;629(8013):951–956.

Observation of a promethium complex in solution. Driscoll DM, White FD et al. Nature. 2024 May 23;629(8013):819-823.

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1. Son Y, Kenny TC et al. Nature. 2024 May 16;629(8012):710–716.

Structural and molecular basis of choline uptake into the brain by FLVCR2. Cater RJ, Mukherjee D et al. Nature. 2024 May 16;629(8012):704–709.

Growth phase-dependent reorganization of cryptophyte photosystem I antennae. Zhang S, Si L et al. Commun Biol. 2024 May 11;7(1):560.

Promiscuous G-protein activation by the calcium-sensing receptor. Zuo H, Park J et al. Nature. 2024 May 9;629(8011):481–488.

Structural insights into vesicular monoamine storage and drug interactions. Ye J, Chen H et al. Nature. 2024 May 2;629(8010):235–243.

Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules. Dodd DO, Mechaussier S et al. Science. 2024 Apr 26;384(6694):eadf5489.

Necroptosis blockade prevents lung injury in severe influenza. Gautam A, Boyd DF et al. Nature. 2024 Apr 25;628(8009):835–843.

Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum. Sun SY, Segev-Zarko L-a et al. mBio. 2024 Apr 10;15(4):e0286423.

Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1-Fo coupling. Sharma S, Luo M et al. Nat Struct Mol Biol. 2024 Apr;31(4):657-666.

Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Hayes TK, Aquilanti E et al. Nat Commun. 2024 Mar 28;15(1):2742.

Parental histone transfer caught at the replication fork. Li N, Gao Y et al. Nature. 2024 Mar 28;627(8005):890–897.

Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Ying W, Wang Y et al. Science. 2024 Mar 22;383(6689):eadj4591.

Flexibility of binding site is essential to the Ca(2+) selectivity in EF-hand calcium-binding proteins. Lai R, Li G, Cui Q. J Am Chem Soc. 2024 Mar 20;146(11):7628-7639.

Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Finci LI, Chakrabarti M et al. Commun Biol. 2024 Mar 2;7(1):260.

Activation of human STING by a molecular glue-like compound. Li J, Canham SM et al. Nat Chem Biol. 2024 Mar;20(3):365-372.

A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Mattson NM, Chan AKN et al. Nat Struct Mol Biol. 2024 Mar;31(3):465-475.

Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection. Zhu S, Bradfield CJ et al. Science. 2024 Mar 1;383(6686):eabm9903.

A new family of bacterial ribosome hibernation factors. Helena-Bueno K, Rybak MY et al. Nature. 2024 Feb 29;626(8001):1125–1132.

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation. Brito C, Serna M et al. Science. 2024 Feb 23;383(6685):870-876.

SlyB encapsulates outer membrane proteins in stress-induced lipid nanodomains. Janssens A, Nguyen VS et al. Nature. 2024 Feb 15;626(7999):617–625.

DockOpt: A tool for automatic optimization of docking models. Knight IS, Mailhot O et al. J Chem Inf Model. 2024 Feb 12;64(3):1004-1016.

Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III. Jiang B, Gao L et al. Science. 2024 Feb 9;383(6683):622-629.

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. Montoya S, Bourcier J et al. Science. 2024 Feb 2;383(6682):eadi5798.

Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells. Kocanova S, Raynal F et al. Life Sci Alliance. 2024 Feb;7(2):e202302154.

Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH. Kumar N, Sharma S, Kaushal PS. Nat Commun. 2024 Jan 20;15(1):638.

A new antibiotic traps lipopolysaccharide in its intermembrane transporter. Pahil KS, Gilman MSA et al. Nature. 2024 Jan 18;625(7995):572–577.

From structural polymorphism to structural metamorphosis of the coat protein of flexuous filamentous potato virus Y. Kavčič L, Kežar A et al. Commun Chem. 2024 Jan 17;7(1):14.

Observation of a single protein by ultrafast X-ray diffraction. Ekeberg T, Assalauova D et al. Light Sci Appl. 2024 Jan 12;13(1):15.

Multilayer DNA origami with terminal interfaces that are flat and wide-area. Kilwing L, Lill P et al. ACS Nano. 2024 Jan 9;18(1):885-893.

Two-step covalent docking with attracting cavities. Goullieux M, Zoete V, Röhrig UF. J Chem Inf Model. 2023 Dec 25;63(24):7847-7859.

Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2. Zhu H, Tonelli F et al. Science. 2023 Dec 22;382(6677):1404-1411.

Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex. Kao C-F, Liu C-Y et al. J Virol. 2023 Dec 21;97(12):e0134323.

Structural insights into intron catalysis and dynamics during splicing. Xu L, Liu T et al. Nature. 2023 Dec 21;624(7992):682-688.

FOXP3 recognizes microsatellites and bridges DNA through multimerization. Zhang W, Leng F et al. Nature. 2023 Dec 14;624(7991):433–441.

Sialoglycan binding triggers spike opening in a human coronavirus. Pronker MF, Creutznacher R et al. Nature. 2023 Dec 7;624(7990):201–206.

Regulation of the cell division hydrolase RipC by the FtsEX system in Mycobacterium tuberculosis. Li J, Xu X et al. Nat Commun. 2023 Dec 4;14(1):7999.

Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease. Zielinski M, Peralta Reyes FS et al. Nat Neurosci. 2023 Dec;26(12):2073-2080.

Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Noddings CM, Johnson JL, Agard DA. Nat Struct Mol Biol. 2023 Dec;30(12):1867-1877.

Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling. Mogila I, Tamulaitiene G et al. Science. 2023 Dec 1;382(6674):1036-1041.

Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Pidathala S, Liao S et al. Nature. 2023 Nov 30;623(7989):1086-1092.

Mechanism of target site selection by type V-K CRISPR-associated transposases. George JT, Acree C et al. Science. 2023 Nov 17;382(6672):eadj8543.

Structure and activation mechanism of the rice Salt Overly Sensitive 1 (SOS1) Na+/H+ antiporter. Zhang XY, Tang LH et al. Nat Plants. 2023 Nov;9(11):1924-1936.

A practical guide to machine-learning scoring for structure-based virtual screening. Tran-Nguyen VK, Junaid M et al. Nat Protoc. 2023 Nov;18(11):3460-3511.

Molecular orbital and topological electron density study of n → π* interactions: amides and thioamides cases. Briceño-Vargas FM, Quesadas-Rojas M et al. RSC Adv. 2023 Oct 26;13(45):31321-31329.

Structures illustrate step-by-step mitochondrial transcription initiation. Goovaerts Q, Shen J et al. Nature. 2023 Oct 26:622(7984):872–879.

Molecular mechanism of de novo replication by the Ebola virus polymerase. Peng Q, Yuan B et al. Nature. 2023 Oct 19;622(7983):603–610.

Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology. Sun C, Zhu H et al. Nature. 2023 Oct 5;622(7981):195–201.

Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Zhang Z, Shibata T et al. Nature. 2023 Oct 5;622(7981):188–194.

Structural basis of the allosteric inhibition of human ABCG2 by nanobodies. Irobalieva RN, Manolaridis I et al. J Mol Biol. 2023 Oct 1;435(19):168234.

Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Zhang D, Ivica J et al. Nature. 2023 Sep 28;621(7980):877–882.

Descriptor-driven de novo design algorithms for DOCK6 using RDKit. Duarte Ramos Matos G, Pak S, Rizzo RC. J Chem Inf Model. 2023 Sep 25;63(18):5803-5822.

Structural basis for inactivation of PRC2 by G-quadruplex RNA. Song J, Gooding AR et al. Science. 2023 Sep 22;381(6664):1331-1337.

Structural basis of mitochondrial protein import by the TIM23 complex. Sim SI, Chen Y et al. Nature. 2023 Sep 21;621(7979):620–626.

Neutralization, effector function and immune imprinting of Omicron variants. Addetia A, Piccoli L et al. Nature. 2023 Sep 21;621(7979):592–601.

A pentameric TRPV3 channel with a dilated pore. Lansky S, Betancourt JM et al. Nature. 2023 Sep 7;621(7977):206–214.

DELE1 oligomerization promotes integrated stress response activation. Yang J, Baron KR et al. Nat Struct Mol Biol. 2023 Sep;30(9):1295-1302.

OPA1 helical structures give perspective to mitochondrial dysfunction. Nyenhuis SB, Wu X et al. Nature. 2023 Aug 31;620(7976):1109–1116.

Computation of absolute binding free energies for noncovalent inhibitors with SARS-CoV-2 main protease. Ghahremanpour MM, Saar A et al. J Chem Inf Model. 2023 Aug 28;63(16):5309-5318.

Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Liu CP, Yu Z et al. Science. 2023 Aug 25;381(6660):eadd8673.

Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus. Wang Y, Zhang C et al. Signal Transduct Target Ther. 2023 Aug 22;8(1):323.

Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Guan H, Wang P et al. Nature. 2023 Aug 17;620(7974):669-675.

Structural basis for the binding of DNP and purine nucleotides onto UCP1. Kang Y, Chen L. Nature. 2023 Aug 3;620(7972):226–231.

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I. Grba DN, Chung I et al. Sci Adv. 2023 Aug 2;9(31):eadi1359.

Electrostatic ratchet for successive peptide synthesis in nonribosomal molecular machine RimK. Ohnuki J, Arimura Y et al. J Am Chem Soc. 2023 Jul 26;145(29):15963-15970.

Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology. Zheng F, Georgescu RE et al. Cell Rep. 2023 Jul 25;42(7):112694.

Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Li M, Oliveira Passos D et al. Sci Adv. 2023 Jul 21;9(29):eadg5953.


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